Differentiation induction of murine erythroleukemia cells by butylated hydroxytoluene

Inhibition of norepinephrine uptake into synaptic vesicles by butylated hydroxytoluene.

Erythroleukemia Cells Effects of Trichostatins on Differentiation of Murine

The fungistatic antibiotics trichostatins (IS) A and C were isolated from culture broth of Streptomyces platensis No. 145 and were found to be potent inducers of differentiation in murine erythroleukemia (Friend and RV133) cells at concentrations of 1.5 x IO" M for TSA and 5 x 10" M for TSC. Differentiation induced by IS was cooperatively en hanced by UV irradiation but not by treatment with di...

Calcium influx in induced differentiation of murine erythroleukemia cells.

Murine erythroleukemia cells (MELC) have served as a model for examining the regulation of erythroid differentiation. However, the role of Ca2+ in the signal transduction pathways regulating differentiation remains unclear. To begin to address this uncertainty we have characterized the regulation of cytoplasmic Ca2+ and the possible role of calcium channels during induced differentiation in MEL...

Changes in DMA Associated with Induction of Erythroid Differentiation by Dimethyl Sulfoxide in Murine Erythroleukemia Cells1

The Friend virus-infected murine erythroleukemia cell can be induced to differentiate along erythroid cells in culture with various compounds, including dimethyl sulfoxide. DNA from murine erythroleukemia cells cultured with dimethyl sulfoxide shows a decrease in sedimenta tion rate in alkaline sucrose gradients after alkali lysis of the cells. These changes can be detected as early as 27 hr af...

Induction of Terminal Differentiation in Human K 562 Erythroleukemia Cells

We have previously demonstrated that continuous exposure of human HL-60 human promyelocytes to 1-fl-D-arabinofuranosylcytosine (araC) results in the induction of terminal differentiation to monocyte-like cells. The present study extends these findings by demonstrating that ara-C induces hemoglobin synthesis in human K562 erythroleukemia cells. This effect occurs maximally at an ara-C concentrat...